Abstract

Author:
Giwa Suleiman, Agbonlahor Dennis, Pius Omoruyi Omosigho, Omene Ogheneakporobo Bridget, Dike Adobi Ezioma, Isah Sadiq Yelwa

Doi: 10.26480/jhcdc.02.2025.88.93

This is an open access article distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Antimicrobial resistance (AMR) has become an important public health challenge, especially in low- and middle-income countries (LMIC). Strains of S. aureus have developed resistance to antimicrobial agents and their prevalence outside the hospital is of potential epidemiological threat. The aim of the study is to determine the prevalence of MRSA strains associated with bacteremia in Lagos state, Nigeria. A total of 299 Staphylococcus isolates were obtained from patients experiencing bacteremia. Results showed that 72(24.1%) of isolates were cefoxitin-resistant, indicating the presence of MRSA. The antimicrobial susceptibility profile of S. aureus revealed complete resistance to amoxicillin (100%) and high sensitivity to ofloxacin (75.9%). MRSA was most prevalent in individuals aged 41–60 years (36.1%), and in males (62.5%), although neither age nor gender differences were statistically significant. Regionally, Lagos West recorded the highest MRSA prevalence (66.7%), followed by Lagos Central (26.4%) and Lagos East (6.9%), but the difference was not statistically significant (p = 0.121). In conclusion, the study reveals a significant public health concern. MRSA remains a major contributor to bloodstream infections, highlighting the persistent challenge of antibiotic resistance in clinical settings. The data emphasize the importance of routine antimicrobial susceptibility testing, early detection, and effective infection control measures.