Abstract

Author:
Olufemi David Olaniyia, Musa Abidemi Muhibi, Odekunle Bola Odegbemi Mathew Folaran Olaniyan, Adebusola Adeola Shakunle, Obiageri Ihuarulam Okioma, Tasleem Olwakemi Folorunso-Daviesa, Abdulwaheed Ade wale Ademosuna

Doi: 10.26480/jhcdc.02.2025.107.111

This is an open access article distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Hepatitis B virus (HBV) infection is a significant global health issue, affecting approximately 296 million individuals worldwide. This study aims to correlate liver Parameters with C-Reactive Protein, D-dimer And Viral Load In HBV Infected individuals attending Federal Medical Centre, Abuja. It is a cross-sectional study involving 145 adult participants (95 HBV-positive individuals comprising 43 females and 52 males while the 50 controls are made up of 26 females and 24 males). Liver function parameters were determined using standard biochemical methods while CRP and D-dimer assays were determined using Electro Chemiluminescence Immunoassay, and viral load quantification using real-time PCR. Results indicated significantly elevated levels of liver enzymes (AST, ALT, ALP), total and direct bilirubin, and CRP in the HBV-positive group compared to controls (p < 0.001). D-dimer levels showed no significant difference (p = 0.837). A positive correlation was observed between viral load and liver enzymes, bilirubin, and CRP (p < 0.05). Multiple logistic regression identified elevated AST, ALT, total bilirubin, and prolonged infection duration as significant predictors of high viral load. In conclusion, integrating liver function tests, CRP, D-dimer, and viral load measurements provides a comprehensive profile of HBV infection diagnosis. These findings underscore the importance of using multiple biomarkers for improved diagnosis and management of HBV.