Abstract

Author:
Abhishek Singh, Ajit Kumar, Ajay Kumar, Yangzin Lamo, Sarin P. John

Doi: 10.26480/jhcdc.01.2022.08.10

This is an open access article distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

To compare Biochemical Parameters and Electrolytes in patients undergoing major abdominal & gynaecological surgeries. 60 patients of either gender of ASA grade I and II scheduled for abdominal & gynaecological surgeries in 9 months durations at AIIMS, Rishikesh were recruited for the study. Patients were divided into 2 groups. Group I was conventional (‘traditional practice’) intravenous fluid group in which balanced salt solution was given as 10 mL/kg bolus followed by 8 mL/kg/hour as infusion until the end of surgery. Group II was restrictive (‘zero balance’) intravenous fluid group in which balanced salt crystalloid at 5 mL/kg/hour as infusion was administered until the end of surgery. Parameters studied were weight, height, BMI, blood urea level, serum creatinine, serum cystatin C levels, serum sodium, serum potassium, serum chloride and eGFR level. Mean age of patients in group I was 47.7 years and in group II was 47.6 years. The mean weight was 54.7 Kgs in group I and 57. Kgs in group II. The mean height was 162.2 cms in group I and 162.6 cms in group II. The mean BMI was 15.1 kg/m2 in group I and 16.04 kg/m2 in group II. The difference found to be non- significant (P> 0.05). Restricted fluid therapy resulted in an increased risk of renal injury as depicted by higher increase in cystatin C levels and resultant fall in estimated GFR.